Programme

Preliminary Programme

Montevideo, Uruguay · 23–26 February 2027 · Arrival Monday 22.

🚧 This programme is under construction. Talk titles and some speakers are still to be confirmed.

Monday

22 Feb

All day

Arrival & registration

Tuesday

23 Feb

09:00–09:50

Laura Sepp-Lorenzino

Welcome from OTS and introduction to oligonucleotide therapeutics

09:50–10:40

Emanuele Buratti

Introduction to RNA splicing

10:40–11:10

Coffee break

11:10–12:00

Alberto Kornblihtt

Control of alternative splicing using siRNAs

12:00–13:30

Lunch

13:30–14:20

Pablo D. Dans

In-silico modelling of oligonucleotides

14:20–15:10

Victoria Calzada

Therapeutic aptamers

15:10–15:30

Coffee break

15:30–16:20

Invited lecture

16:20–17:10

Round table: The journey from the academic lab into global biotech

17:10–18:00

Short talks selected from submitted abstracts

Wednesday

24 Feb

09:00–09:50

Manuel de la Mata

miRNAs and their degradation mechanisms

09:50–10:40

Federico Ariel

Long non-coding RNAs and RNAi in field crops for sustainable agriculture

10:40–11:10

Coffee break

11:10–12:00

Rodrigo Galindo-Murillo

Molecular Modeling of Antisense Oligonucleotide Analogs

12:00–13:30

Lunch — Winery visit

13:30–14:20

Frank Slack

Towards microRNA therapeutics in cancer

14:20–15:10

Modesto Orozco

pH-driven dynamics and mechanisms of LNP-mediated siRNA delivery

15:10–15:30

Coffee break

15:30–16:20

Zoya Ignatova

Expanding the functional landscape of tRNAs beyond translation into therapeutics

16:20–18:00

Poster session

20:00 onwards

Asado — Barbecue

Thursday

25 Feb

09:00–09:50

Juan Pablo Tosar

Naked RNA uptake, sensing, and endosomal escape

09:50–10:40

Saumya Das

Less may be more: the evolving role of tRNA-derived small RNAs in biology and therapeutics

10:40–11:10

Coffee break

11:10–12:00

Macarena Hernández

Therapeutic Aptamers in Clinical Translation: The ApTOLL Story

12:00–13:30

Lunch

13:30–14:20

Samir El Andaloussi

Extrahepatic delivery of RNA and CRISPR therapeutics using engineered non-viral delivery systems

14:20–15:10

Annemieke Aartsma-Rus

Exon skipping for Duchenne muscular dystrophy: applying 25 years of expertise to future optimization

15:10–15:30

Coffee break

15:30–16:20

Adrián R. Krainer

The making of Nusinersen and current frontiers in splice-switching ASOs

16:20–17:10

Alberto Kornblihtt

ASOs, transcription and chromatin structure

17:10–18:00

Isabel Aznarez

Regulation of mRNA decay with ASOs for gene expression activation

Friday

26 Feb

09:00–09:50

Invited talk to be confirmed

09:50–10:40

Muthiah Manoharan

New frontiers and current challenges in siRNA design

10:40–11:10

Coffee break

11:10–12:00

Laura Sepp-Lorenzino

CRISPR Therapeutics: ex vivo and in vivo

12:00–18:00

Winery visit & farewell