Preliminary Programme

Laura Sepp-Lorenzino

Lecture: Welcome from OTS and introduction to oligonucleotide therapeutics

Emanuele Buratti

Lecture: Introduction to RNA splicing

Alberto Kornblihtt

Lecture: Control of alternative splicing using siRNAs

Pablo D. Dans

Lecture: In-silico folding of aptamers and computer-aided design of siRNAs

Victoria Calzada

Lecture: Therapeutic aptamers

Manuel de la Mata

Talk: miRNAs and their degradation mechanisms

Federico Ariel

Talk: Long non-coding RNAs and RNAi in field crops for sustainable agriculture

Rodrigo Galindo-Murillo

Talk: Molecular Modeling of Antisense Oligonucleotide Analogs

Frank Slack

Talk: Towards microRNA therapeutics in cancer

Modesto Orozco

Talk: pH-driven dynamics and mechanisms of LNP-mediated siRNA delivery

Zoya Ignatova

Talk: Expanding the functional landscape of tRNAs beyond translation into therapeutics

Juan Pablo Tosar

Talk: Naked RNA uptake, sensing, and endosomal escape

Saumya Das

Talk: Less may be more: the evolving role of tRNA-derived small RNAs in biology and therapeutics

Macarena Hernández

Talk: Therapeutic Aptamers in Clinical Translation: The ApTOLL Story

Samir El Andaloussi

Talk: Extrahepatic delivery of RNA and CRISPR therapeutics using engineered non-viral delivery systems

Annemieke Aartsma-Rus

Talk: Exon skipping for Duchenne muscular dystrophy: applying 25 years of expertise to future optimization

Adrián R. Krainer

Talk: The making of Nusinersen and current frontiers in splice-switching ASOs

Alberto Kornblihtt

Talk: ASOs, transcription and chromatin structure

Isabel Aznarez

Talk: Regulation of mRNA decay with ASOs for gene expression activation

Muthiah Manoharan

Talk: New frontiers and current challenges in siRNA design

Laura Sepp-Lorenzino

Talk: CRISPR Therapeutics: ex vivo and in vivo